Neisseria gonorrhoeae strains resently isolated from clinical specimens of prostitutes were examined for serogrouping, auxotyping, antibiotic susceptibility and the existence of penicillinase producicing N. gonorrheae strain(PPNG). Among the 57
N.
gonorrheae isolates, one strain has WI serogroup and the other 56WII/III serogroup strains were 17 PPNGs(30.4%). Nearly 98% of 47 N. gonorrheae strains were assigned to three major auxotypic groups (Wild, pro or pro Arg) as determined by their
requirements for none or proline or proline and arginine on chemically defined medium. One strain failed to grow on chemically defined medium, but could grow on gonococcal medium with 1% of fetal bovine serum. Pro(66.7%) and Wlid(31.25%) groups
were
more common than Pro Arg(6.25%). However, auxotypes were different in their ability to produce penicillinase. Thirty three non-PPNG isolates were Pro(57.6%), Wild(30.3%) or Pro Arg(9.1%), but 15 PPNG isolates included were only two auxatypes,
Pro(66.7%)
and Wild(33.3%). All the N. gonorrheae isolates tested were relatively resistant to penicillin G, ampicillin or gentamicin, but Pro Arg group was more susceptible to ampicillin, tetracyclin and chloramphenicol than Wild or Pro groups. Especially,
ampicillin was the most effective drug against wild and Pro Agr group of non-PPNG strains.
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